Spray Characterization Testing
Comprehensive Spray Testing for Orally Inhaled & Nasal Drug Products (OINDPs)
From early development through regulatory submission, Proveris Laboratories provides comprehensive, regulatory-ready spray characterization for pMDIs, DPIs, SMIs, and nasal sprays. Using industry-standard instrumentation under patient-relevant actuation conditions, we generate high-quality data capturing meaningful performance trends to support formulation optimization, device development, and global regulatory submissions.
Built to Support Confident Regulatory & Development Decisions
At Proveris Labs, we combine cutting-edge technology and methods to replicate real-world conditions:
Alignment with regulatory expectations
Fewer late-stage surprises
Greater confidence in device and formulation performance
Reproducible, automation-driven results
Performance-Driven Spray Characterization
Spray Formation
Analyze spray shape, velocity, and duration for targeted delivery.
Dose Delivery
Ensure consistent dose with every acuation.
Device Operation
Assess priming, re-priming, and actuation to confirm consistent, reliable performance.
Deposition Behavior
Characterize droplet and particle size to predict regional deposition in the airway.
Understand How Your Spray Is Formed
Spray Pattern & Plume Geometry
Reveal spray shape, symmetry, plume width, and angle to confirm consistent spray formation and regulatory alignment.
Plume Front Velocity & Spray Duration
Quantify how fast and how long the spray is delivered — critical for targeting nasal and pulmonary regions.
Why this matters:
Confirms spray formation, directionality, and timing — helping optimize device mechanics and formulation behavior.
Understand What Dose Is Delivered
Pump Delivery / Dose Weight
Measure total delivered mass per actuation to confirm consistent pump performance.
Dose Content (SAC / DDU)
Verify dose content and uniformity across the life of the device (beginning, middle, end).
Why this matters:
Confirms dosing consistency and supports regulatory expectations for content uniformity.
Understand How the Device Is Used
Priming / Re-Priming
Evaluate the number of actuations required to prepare the device for consistent delivery.
Actuation Force
Measure force and force-time profiles to confirm consistent, reliable device operation throughout the product’s life.
Why this matters:
Ensures the device performs reliably and predictably for each actuation, supporting overall product performance and regulatory alignment.
Understand Where the Drug Will Deposit
Droplet Size Distribution (DSD)
Characterize droplet size to predict nasal or lung regional deposition.
APSD / Drug in Small Particles or Droplets (DSPD)
Quantify aerodynamic particle size and fine particle fraction to assess inhalable and respirable delivery.
Why this matters:
Links spray performance to expected site of deposition and therapeutic delivery.
Why Choose Proveris Labs for Spray Characterization?
Proprietary Technology
SprayVIEW® and Vereo® platforms deliver unmatched precision, automation, and reproducibility — minimizing operator variability.
OINDP-Focused Expertise
Over 30 years dedicated exclusively to inhaled and nasal drug product testing.
Regulatory Confidence
GMP-compliant, ISO 9001 certified, FDA-registered — supporting FDA, EMA, and global submissions.
Patient-Relevant Insight
Data reflects real-world actuation and use, not just idealized lab conditions.
End-to-End Support
From early method development through IVBE and regulatory submission.